Table 1. Summary of Observed Drug Effects in the Cardiac MPS for Two Cell Lines and Literature Values from Other 3D hiPSC CM Tissue Formats.

drug	studies	TdP risk	Cmax (μM)	prediction	cAPD80	triangulation	arrhythmia or no beating	matches prediction?
dofetilide	MPS WTC	high	0.002	↑ QT, ↑TdP20	↑ 0.0001 μM	↑ 0.0001–0.001 μM	↑ 0.01–1 μM	yes
	MPS SCVI20				↑ 0.01 μM	↑ 0.1 μM	↑ 0.01–1 μM	yes
	Biowire31				↑ 10–1000 nM			yes
	tissue rings32						↑25a nM32	yes
bepridil	MPS WTC	high	0.032	↑ QT, ↑TdP20	↑ 0.0032–3.2 μM	↑ 3.2–32 μM	N/A	partly (QT)
	MPS SCVI20				N/A	N/A	↑ 32 μM	partly (TdP)
amiodarone	MPS WTC	intermed	0.0008	↑ QT, ↑TdP5	↑ 0.01–1 μM	N/A	N/A	partly (QT)
	MPS SCVI20				N/A	N/A	↑ 0.01–1 μM	partly (TdP)
terfenadine	MPS WTC	intermed	0.00028	↑ QT, ↑TdP5,20	N/A	N/A	↑ 0.3–3 μM	yes
	MPS SCVI20				↓ Dose5	N/A	↑ 0.003–3 μM	yes
	anisotropy strip33						↑ reentry events 300 nMa	yes
nifedipine	MPS WTC	low	0.0077	↑TdP20	↓ 0.1–1 μM	↑ 1 μM	N/A	yes
	MPS SCVI20				N/A	↑ 10 μM	↑ 0.1–10 μM	yes
	tissue rings30				↑ 30 nM–1 μMa30			yes
mexiletine	MPS WTC	low	2.5	↓ QT,11INaL block	N/A	↑ 100 μM	↑ 100–1000 μM	yes
	MPS SCVI20				↓ 100 μM	↑ 100 μM	↑ 100–1000 μM	yes
lidocaine	MPS WTC	low	2.5	N/A,5INaL block	N/A	N/A	↑ 100–1000 μM	yes
	MPS SCVI20				N/A	N/A	↑ 1000 μM	yes
	tissue rings34						no arrhythmia events 100 μMa	yes

^aParameter available in the literature not identical to the parameter used in this publication but comparable.