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. 2022 Aug 16;10:61. doi: 10.1186/s40364-022-00407-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Circ_0009043 functioned as a sponge for miR-148a-3p in NSCLC cells. A RT-qPCR was performed for ascertaining the expression of miR-148a-3p in NSCLC tissues compared with normal lung tissues. (B) Correlations between circ_0009043 and miR-148a-3p. C Online bioinformatics analysis showed the binding within that of miR-148a-3p in addition to 3’-UTR of circ_0009043. D Expression level of miR-148a-3p in the HCC827 and A549 cells of the 5 groups (CTRL, OE-CTRL, OE- Circ, shCTRL and shCirc groups) were determined by RT-qPCR. E–F Determination of the physical interaction between circ_0009043 and miR-148a-3p by RNA immunoprecipitation experiments. G The activity of circ_0009043-wt plasmid in A549 cells was suppressed by the mimic transfection of miR-148a-3p which was demonstrated by luciferase reporter assay. ***P < 0.001; ****P < 0.0001