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. 2022 Aug 16;20:276. doi: 10.1186/s12916-022-02451-9

Table 3.

Results of model estimating change in % FMD at 3- and 6-month follow-ups of cessation subgroup (upper section) and changes in means (difference over baseline) in %FMD for the cessation subgroup for 3- and 6-month follow-ups (lower section)

Variables Group/follow-up B-coeff Exp (B) 95% CI p value
Lower Upper
%FMD
Group NRT over EC nicotine-containing 0.46 1.61 − 0.59 1.54 0.38
EC nicotine-free over EC nicotine-containing − 0.57 0.57 − 1.74 0.60 0.34
Follow-up 3 m over baseline 2.40 20.04 1.66 3.14 < 0.0001
6 m over baseline 2.99 11.04 2.22 3.77 < 0.0001
Gender Male over female − 1.35 0.26 − 2.27 − 0.43 0.004
Age − 0.02 0.98 − 0.05 0.01 0.27
Intercept 7.67 5.92 9.42 < 0.0001
%FMD changes over baseline NRT EC—nicotine-containing EC – nicotine-free
Mean difference 95% CI p value Mean difference 95% CI p value Mean difference 95% CI p value
Lower Upper Lower Upper Lower Upper
3 months over baseline
Cessation subgroup 2.61 0.97 4.25 0.003 3.94 1.73 6.15 0.001 4.78 2.27 7.29 0.001
6 months over baseline
Cessation subgroup 4.40 2.18 6.66 0.001 2.96 1.17 4.74 0.002 2.97 0.90 5.04 0.006

%FMD, percentage change in flow-mediated dilation