Table 4.

Quality of life by domain at baseline, 3 and 6 months follow-ups of all participants

Baseline, 3 and 6 months, mean	Nicotine replacement therapy	Nicotine-containing e-cigarettes	Nicotine-free e-cigarettes	F value, p value, and degrees of freedom
Mobility (%)
Baseline	9.88	15.48	13.92	F = 0.60, p = 0.55, df = 2,243
3 months	7.41	9.52	10.13	F = 0.20, p = 0.82, df = 2,243
6 months	6.17	7.14	8.86	F = 0.21, p = 0.81, df = 2,243
Self-care (%)
Baseline	2.47	5.95	3.80	F = 0.65, p = 0.52, df = 2,243
3 months	2.47	2.38	1.27	F = 0.12, p = 0.84, df = 2,243
6 months	1.23	3.57	2.53	F = 0.20, p = 0.82, df = 2,243
Usual activity (%)
Baseline	8.64	16.67	18.99	F = 1.89, p = 0.15, df = 2,243
3 months	7.41	14.29	12.66	F = 1.04, p = 0.36, df = 2,243
6 months	6.17	15.48	10.13	F = 1.90, p = 0.15, df = 2,243
Pain (%)
Baseline	35.80	39.29	46.84	F = 1.05, p = 0.35, df = 2,243
3 months	23.46	25.00	29.11	F = 0.35, p = 0.70, df = 2,243
6 months	17.28	21.43	34.18	F = 3.43, p = 0.03, df = 2,243
Depression/anxiety (%)
Baseline	38.27	45.24	51.90	F = 1.50, p = 0.22, df = 2,243
3 months	23.46	42.86	43.04	F = 4.54, p = 0.01, df = 2,243
6 months	24.69	50.00	44.30	F = 6.25, p = 0.01, df = 2,243
QALY (%)
Baseline	41.98	34.52	32.91	F = 0.81, p = 0.45, df = 2,243
3 months	62.96	44.05	43.04	F = 4.17, p = 0.02, df = 2,243
6 months	64.20	42.86	43.04	F = 5.03, p = 0.01, df = 2,243
VAS (Mean, SD)
Baseline, mean (SD)	71.59 (15.98)	67.26 (15.24)	70.96 (17.14)	F = 1.74, p = 0.18, df = 2,243
3 months, mean (SD)	72.38 (14.33)	70.91 (14.42)	69.81 (19.24)	F = 0.51, p = 0.60, df = 2,243
6 months, mean (SD)	75.38 (13.80)	70.29 (16.12)	72.78 (16.22)	F = 2.24, p = 0.11, df = 2,243