Fig. 2.

AD_be inoculation accelerates amyloidosis in APP_swe/PS1_dE9 mice in proximity to the injection site. a–d Representative images of 4G8 immunolabelling showing Aβ pathology in the hippocampus (a, b) and alveus (c, d) of APP_swe/PS1_dE9 mice eight months after human brain inoculation. e, f Quantification of Aβ load (4G8-positive Aβ plaques per 100 µm²) revealed that AD_be inoculation accelerates Aβ deposition in the hippocampus (e, Mann Whitney's test, U = 21.5, p < 0.0001) and alveus (f, Mann Whitney's test, U = 5, p < 0.0001). ****p < 0.0001. n_Ctrl = 15, n_AD1 = 15 (light pink in e, f), n_AD2 = 20 mice (dark pink in e, f). Data are shown as mean ± s.e.m. Scale bars = 100 µm