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. 2022 Aug 16;10:112. doi: 10.1186/s40478-022-01410-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — AD_be inoculation increases tau pathology in APP_swe/PS1_dE9 mice in proximity to to the injection site. AT8 immunolabelling revealed tau lesions in the forms of neuropil threads (a), NFTs (b–d), neuritic plaques (e) around the injection site of AD_be-inoculated APP_swe/PS1_dE9 mice at 8 mpi. Neuritic plaques were also detected in Ctrl_be-inoculated mice at 8 mpi (f). AT8 immunolabelling of non-inoculated aged APP_swe/PS1_dE9 mice (24 months old) also revealed neuritic plaques (g). h, i Representative images of AT8 immunolabelling showing tau pathology induction in the dorsal hippocampus of an AD_be-inoculated APP_swe/PS1_dE9 mouse at 8 mpi (i) compared to a Ctrl_be-inoculated littermate (h). j, k Representative images of AT8 immunolabelling showing tau pathology induction in the alveus of an AD_be-inoculated APP_swe/PS1_dE9 mouse at 8 mpi (k) compared to a Ctrl_be-inoculated littermate (j). Scale bars = 20 µm (a–g), 500 µm (h, i) and 100 µm (j, k) and 20 µm (i inset)