Table 2.
The effects of E. globulus leaf solvent fractions against P. berghei infected mice in the 4-day suppressive test
| Treatments | % Parasitemia | % Parasitemia suppression | Mean survival time (day) |
|---|---|---|---|
| 2%tween 80 (10 ml/kg) | 34.67 ± 2.16 | – | 9.50 ± 0.99 |
| CQ (25 mg/kg) | 0.00 ± 0.00 | 100.00 ± 0.00a3 | 29.50 ± 0.34a3 |
| CF (mg/kg) 100 | 17.00 ± 0.89 | 52.91 ± 3.43a3b3 | 16.83 ± 0.95 a3b3 |
| 200 | 12.33 ± 0.67 | 66.08 ± 1.58a3b3 | 17.17 ± 0.48a3b3 |
| 400 | 11.00 ± 0.93 | 69.93 ± 2.01a3b3 | 19.00 ± 1.06a3b3 |
| EAF (mg/kg) 100 | 16.00 ± 0.97 | 53.71 ± 1.64a3b3 | 16.00 ± 0.73a3b3 |
| 200 | 13.67 ± 0.71 | 60.31 ± 1.66a3b3 | 16.17 ± 1.01a3b3 |
| 400 | 10.83 ± 0.79 | 68.13 ± 3.05a3b3 | 22.50 ± 0.92a3b3 |
| DW (10 ml/kg) | 36.50 ± 1.65 | – | 9.00 ± 0.73 |
| CQ (25 mg/kg) | 0.00 ± 0.00 | 100.00 ± 0.00a3 | 29.50 ± 0.34a3 |
| AF (mg/kg) 100 | 26.17 ± 1.01 | 23.28 ± 5.05a3b3 | 10.33 ± 1.02 b3 |
| 200 | 22.33 ± 0.95 | 34.01 ± 5.52a3b3 | 12.17 ± 0.75b3 |
| 400 | 16.83 ± 0.91 | 50.61 ± 3.83a3b3 | 15.67 ± 0.67a3b3 |
Data are expressed as mean ± SEM
CF Chloroform fraction, EAF Ethyl acetate fraction, DW Distilled water, AF Aqueous fraction, CQ Chloroquine
1p < 0.05
2p < 0.01, p < 0.001
acompared to negative controls
bcompared to chloroquine