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. Author manuscript; available in PMC: 2022 Aug 16.
Published in final edited form as: Cell Host Microbe. 2022 Jul 15;30(8):1173–1185.e8. doi: 10.1016/j.chom.2022.06.005

Figure 5. Single-cell CITE-seq data reveal that the same NK population that exhibited a distinct transcriptional phenotype associated with B*46 after infection is also present in the absence of HIV infection.

Figure 5.

(A) CITE-seq data from PWOH (n = 9) identified three NK cell clusters.

(B) Gene and protein markers of the specific NK cell cluster differentiated by B*46 during HIV infection in the current three NK cell populations. Statistical significance is denoted for comparisons between one cluster with the combined two other clusters. ****p < 0.0001.

(C) HLA-B is the most differentially expressed gene comparing B*46+ versus B*46− groups.

(D and E) (D) Gene (HLA-B) and (E) protein (HLA class I expression using W6/32 antibody) expression in all clusters were higher in the B*46− group. Statistical significance is denoted for comparisons between the groups within a specific cluster. Statistical significance for gene and protein clusters were determined by the Wilcoxon rank-sum and likelihood ratio tests, respectively. ****p < 0.0001.