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. 2022 Aug 16;18(8):e10663. doi: 10.15252/msb.202110663

Figure EV2. Annotation of the MOFA factors from the endoderm differentiation study.

Figure EV2

Data ref: Cuomo et al (2020b).

  • A
    Heatmap displaying negative log P‐values from GO enrichment analyses based on the absolute values of the loadings of individual MOFA factors (Materials and Methods).
  • B
    Scatter plot of MOFA factors 1 & 2, with color corresponding to the time point of collection (day 0,1,2 & 3 of endoderm differentiation).
  • C
    Scatter plot of MOFA factors 3 & 6, colored by estimated cell cycle phase (G1, G2/M, S; estimated using Seurat).
  • D
    Scatter plot of MOFA factors 1 & 4 capturing respiration.
  • E
    Scatter plot of MOFA factors 8 & 10, capturing a signature linked to response to metal ions, colored by expression of gene with top loadings, MT2A (Materials and Methods). Note that the scatter plots of MOFA factors in panels (B, C and D) are reused as reference in Fig 3.