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. 2022 Jun 26;81(9):1301–1312. doi: 10.1136/annrheumdis-2022-222460

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Population-specific and cross-populational disease-associated loci. (A) CYP1B1 locus, observed in only the UKB datasets, (B) G3BP1 locus, observed in only the BBJ datasets, and (C) POU2AF1 locus, observed consistent effect in both ancestries are described as follows. (Left) Regional plot of the individual locus. The lead variants are coloured in purple and all the other variants are coloured based on LD with the lead variant as in the legend. (Middle) Histograms of the alternative allele frequency of the lead variants, which are coloured according to continental populations. (right) Forest plot of the individual lead variants. The dots indicate the OR in each dataset and the whiskers represent 95% confidence intervals. AD, atopic dermatitis; BA, bronchial asthma; BBJ, BioBank Japan; GD, Grave’s diseases; PO, pollinosis; RA, rheumatoid arthritis; T1D, type 1 diabetes; UKB, UK Biobank.