Table 1.

Summary of the multi-trait meta-analyses

Locus discovery	Cohort	Chr:position	SNP	Gene	Annotation	BioBank Japan					UK BioBank					Cross-population
						EAF (control)	OR	P*	I2	Phet†	EAF (control)	OR	P*	I 2	Phet†	EAF (control)	OR	P*	I2	Phet†
Meta-analysis of allergic diseases
Novel	UKB	1:12 080 122	rs74052928	MIIP	Intron	0.094	0.95	0.029	31	0.24	0.14	0.95	3.0×10−8	0	0.76	0.13	0.95	2.6×10−9	0	0.63
Novel	UKB	2:136 809 603	rs575879774	CXCR4	Intergenic	0.28	1.01	0.46	0	0.78	0.015	1.16	8.4×10−9	0	0.49	0.10	1.05	3.4×10−4	83	1.8×10−5
Novel	UKB	6:108 131 958	rs7773622	SCML4	Intron	0.086	1.01	0.81	67	0.047	0.16	0.96	2.8×10−8	0	0.92	0.13	0.96	2.5×10−7	54	0.053
Novel	Cross-population	8:129 428 433	rs16902902	LINC00824	Intron	0.33	0.93	6.8×10−7	66	0.051	0.037	0.95	6.2×10−4	0	0.89	0.13	0.94	2.1×10−9	27	0.23
Known ‡	UKB	2:38 298 139	rs1800440	CYP1B1	Missense	–	–	–	–	–	0.18	1.05	3.6×10−9	0	0.38	–	–	–	–	–
Known ‡	UKB	2:205 032 379	rs115257668	ICOS	Intergenic	–	–	–	–	–	0.018	1.14	1.2×10−8	0	0.84	–	–	–	–	–
Meta-analysis of autoimmune and allergic diseases
Novel	BBJ	1:14 206 917	rs10803431	PRDM2	Intergenic	0.49	1.07	2.3×10−8	3	0.39	0.37	1.00	0.42	0	0.96	0.41	1.01	0.058	73	2.7×10−5
Novel	BBJ	5:151 169 881	rs2053062	G3BP1	Intron	0.11	0.90	2.9×10−8	0	0.54	–	–	–	–	–	–	–	–	–	–
Known ‡	BBJ	6:135 415 208	rs2210366	HBS1L	Intron	0.36	1.07	2.5×10−8	40	0.14	0.25	1.02	0.03	0	0.62	0.29	1.03	2.9×10−6	62	0.0021
Known ‡	Cross-population	11:111 243 102	rs4529910	POU2AF1	Intron	0.41	0.96	8.3×10−4	71	0.0044	0.73	0.96	5.7×10−8	25	0.25	0.63	0.96	1.9×10−10	54	0.014

*P-value in the fixed effect model by Lin-Sullivan method.

†P-value based on Cochran’s Q test.

‡Newly identified risk variant independent of the previously known risk variant within the locus.

BBJ, BioBank Japan; Chr, chromosome; EAF, effect allele frequency; SNP, single nucleotide polymorphism; UKB, UK Biobank.