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. 2022 Jun 15;81(9):1290–1300. doi: 10.1136/annrheumdis-2022-222156

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Integrative analysis of DNA methylation and gene expression. (A) General description of the significant CpG-gene expression interactions identified in our analysis. (B) Selected examples of specific CpG-gene expression interactions. Box plots representing both the differentially methylated positions (DMPs) and the differentially expressed genes (DEGs). Significant differences are marked (*FDR<0.05). Graphical representation of the correlation of DNA methylation and gene expression of DMP-DEG pairs is also shown. DNA methylation and gene expression levels are illustrated in each subset of individuals. ACT, active disease; CRTL, controls; RT, remission with treatment; RNT, remission without treatment.