TABLE 1.
MICs of β-lactams for E. coli N1949 and NDM-producing E. coli recombinant strains determined by broth microdilution
| β-Lactam(s) | MICs (ug/mL) |
|||||
|---|---|---|---|---|---|---|
|
E. coli isolate | ||||||
| N1949 | TOP10 (NDM-35) | TOP10 (NDM-1) | TOP10 (NDM-5) | TOP10 (NDM-9) | TOP10 | |
| Amoxicillin | >512 | >512 | >512 | >512 | >512 | 4 |
| Ticarcillin | >512 | >512 | >512 | >512 | >512 | 4 |
| Piperacillin | >512 | 256 | 128 | 128 | 256 | 2 |
| Cefoxitin | >512 | 512 | 256 | 256 | >512 | 2 |
| Ceftazidime | >512 | >512 | >512 | >512 | >512 | 0.5 |
| Cefotaxime | >512 | 128 | 256 | 256 | 256 | 0.125 |
| Cefepime | 256 | 8 | 16 | 16 | 16 | 0.5 |
| Aztreonam | 64 | 0.125 | 0.125 | 0.125 | 0.25 | ≤0.125 |
| Aztreonam + avibactama | 8 | 0.125 | 0.125 | 0.125 | 0.125 | ≤0.125 |
| Imipenem | 64 | 32 | 16 | >32 | 16 | 0.125 |
| Meropenem | 128 | 8 | 4 | >32 | 4 | 0.03 |
| Ertapenem | >512 | 32 | 32 | 32 | 32 | 0.015 |
| Temocillin | >512 | 32 | 32 | 32 | 256 | 8 |
| Cefiderocol | 256 | 2 | 1 | 1 | 2 | ≤0.125 |
a
Avibactam supplemented at a concentration of 4 μg/mL.