TABLE 2.

Summary of the meropenem population pharmacokinetic parameter estimates^a

Parameters	Median	95% credibility interval	Mean	SD	Shrinkage (%)
ke, hr−1	1.26	1.07, 1.56	1.33	0.36	0.001
Vplasma, L	5.38	3.98, 7.42	6.14	2.87	0.003
VCSF, L	0.55	0.08, 0.98	0.55	0.42	0.001
Vbrain, L	0.28	0.11, 0.71	0.57	0.70	0.000
k12, hr−1	2.56	0.95, 3.81	2.43	1.56	0.000
k21, hr−1	1.39	1.11, 1.86	1.44	0.46	0.009
k13, hr−1	0.001	4 × 10−4, 0.01	0.003	0.004	0.007
k31, hr−1	0.03	4 × 10−4, 0.08	0.04	0.03	0.001
k14, hr−1	0.02	0.01, 0.03	0.02	0.01	0.004
k41, hr−1	0.52	0.34, 1.20	0.75	0.55	0.001
k34, hr−1	0.67	0.31, 0.81	0.57	0.31	0.001
k43, hr−1	0.04	0, 0.11	0.08	0.13	0.000

^aCSF, cerebrospinal fluid; k_e, elimination rate constant; k_xy, rate of transfer from the compartment x to y, where compartment 1 is the plasma central, 2 is the plasma peripheral, 3 is the CSF, and 4 is the brain compartment; V, central volume of distribution.