FIG 5.

Susceptibility to host innate immunity. Human whole blood (A) and serum (B) killing of PAO1, AM.P2-X-1, Mat-X-1, and Kat-X-2 in active (solid line) and heat inactivated blood/serum (dotted line). For the murine lung infection model, mice were intratracheally infected with PAO1, ΔhmgA, and AM.P2-X-1, and lungs were harvested after 24 h to determine bacterial survival in the host environment (C and D). *, P < 0.05; **, P < 0.005; ****, P < 0.0001, denoted based on one-way or two-way analyses of variance and Dunnett’s test. LOD, limit of detection.