TABLE 1.
Single-dose combination PslGh-PelAh prophylaxis disseminates bacteria in an acute mouse model of pulmonary P. aeruginosa infection
| Treatment | No. of mice with bacteremia | Total no. of mice | % of mice with bacteremia | Odds ratio (95% confidence interval) | Corrected Pa |
|---|---|---|---|---|---|
| Buffer | 5 | 41 | 12.2 | 3.09 (1.03–8.61) | 0.18 |
| PslGh-PelAh | 12 | 40 | 30 | ||
| Ciprofloxacin | 0 | 24 | 0 | NAb | NA |
| Ciprofloxacin + PslGh-PelAh | 0 | 24 | 0 | ||
| Ceftazidime | 1 | 16 | 6.3 | 2.143 (0.22–32.86) | >0.99 |
| Ceftazidime + PslGh-PelAh | 2 | 16 | 12.5 |
a
P values were corrected by the Bonferroni method for three comparisons.
b
NA, not applicable.