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NF-κB-mediated degeneration of human and mouse brain. (A) Scheme of healthy human brain showing a normal sized entorhinal cortex. (B) Human SHARPIN mutated Alzheimer’s disease (AD) brain showing a degenerated entorhinal cortex. (C) Scheme of healthy NF-κB wildtype mouse brain with normal dentate gyrus. (D) NF-κB repression in mice brains leads to a degenerated dentate gyrus.
