Table 2.
Risk or recurrence and hazard ratios by HGF signature status, race and age in Carolina Breast Cancer Study phase 3
| HGF | N (recurrences) | Crude 5-year risk of recurrence | *Standardized 5-year risk of recurrence | *Standardized 5-year Hazard ratio HR (95%CI) | |
|---|---|---|---|---|---|
| HGF- | 901 (79) | 8.76% (6.92, 10.61) | 10.29% (8.01, 12,57) | Referent | |
| HGF+ | 350 (65) | 18.57%(14.49, 22.65) | 18.00% [11.62, 24.38) | 1.88 (1.19, 2.98) | |
|
| |||||
| Non-Black | HGF- | 469 (31) | 6.61% (4.35,8.86) | 7.90% (5.06, 10.74) | Referent |
| HGF+ | 99 (18) | 18.18% (10.55,25.81) | 12.61% (3.54, 21.69) | 1.68 (0.72, 3.90) | |
|
| |||||
| Black | HGF- | 432 (48) | 11.11% (0.81,14.08) | 12.76% (9.18,16.32) | Referent |
| HGF+ | 251 (47) | 18.72% (13.89,23.56) | 20.42% (12.21, 28.62) | 1.73 (1.01, 2.99) | |
|
| |||||
| < 50 | HGF- | 442 (43) | 9.72% (6.96,12.49) | 11.42% (8.00,14.86) | Referent |
| HGF+ | 211 (40) | 18.96% (13.65,24.25) | 20.22% (11.43, 29.01) | 1.95 (1.09, 3.50) | |
|
| |||||
| 50+ | HGF- | 459 (36) | 7.84% (5.38,10.31) | 9.06% (6.10, 12.03) | Referent |
| HGF+ | 139(25) | 17.99% (11.57,24.39) | 15.65% (6.47,24.84) | 1.82 (0.88, 3.75) | |
*
Recurrence was standardized using inverse probability of exposure weights for tumor grade, age, and stage.