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. 2022 Aug 16;13:4819. doi: 10.1038/s41467-022-32229-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Experimental and bioinformatic workflow for multiplexing of 14 hNPC clones derived from 13 individuals. QC, quality control. b UMAP visualization of 30,557 annotated cells from 5 Ctrl and 7 sPD hNPC clones within the clusters NSC: neural stem cells, immature neurons, glial precursors, NCSC: neural crest stem cells and apoptotic NSC / NCSC. c UMAP visualization with annotations for the disease condition (Ctrl, sPD). d Contribution of individual patients to clusters. e RNA velocity analysis revealed two NSC trajectories on immature neurons (NSC1 fate) and NSC populations (NSC2 fate) as well as one developmental point of origin (root) after cell cycle effects were regressed out. f Detail of the network of enriched canonical pathways for DEGs of the root population with edges weighted by the ratio of overlapping gene sets. FDR corrected p-values are represented by q-values. Complete network is presented in Supplementary Fig. 3a.