Table 5.

Risk of spontaneous preterm birth according to concentrations of oxylipins & precursor fatty acids (n =48 including 12 cases of spontaneous preterm birth (25 %)).

	Week 14 (n = 48)				Week 24 (n = 48)
	Below	Above	Odds	p-value	Below	Above	Odds	p-value
	Median	Median	Ratio		Median	Median	Ratio
Omega-6 fatty acids and oxylipins
LA**	17%	35%	2.8	.14	21%	30%	1.7	.43
9-HODE	39%	14%	0.2	.05	22%	26%	1.2	.75
13-HODE	26%	26%	1.0	.98	29%	21%	0.6	.49
9,10-DiHOME	25%	25%	1.0	.99	24%	26%	1.1	.87
13H-9,10E-LA	16%	28%	2.0	.41	27%	23%	0.8	.70
9H-12,13E-LA	25%	26%	1.1	.92	24%	19%	0.7	.62
9,12,13-TriHOME	17%	33%	2.5	.18	24%	25%	1.1	.93
GLA	17%	35%	2.8	.14	21%	30%	1.7	.44
DGLA	33%	17%	0.4	.20	29%	22%	0.7	.64
AA	24%	27%	1.2	.79	12%	39%	5.1	.038
5-HETE	8%	42%	8.2	.014	21%	29%	1.6	.49
12-HETE	21%	29%	1.6	.50	21%	29%	1.6	.50
15-HETE	12%	38%	4.4	.050	17%	33%	2.7	.16
TxB2	13%	32%	3.7	.10	25%	25%	1.0	.97
DTA	29%	22%	0.7	.53	29%	22%	0.7	.58
DPA n-6	25%	26%	1.1	.94	25%	26%	1.1	.91
Omega-3 fatty acids and oxylipins
ALA	17%	35%	2.9	.13	17%	35%	2.8	.15
SDA (18:4 n-3)	15%	38%	3.6	.07	25%	26%	1.1	.93
ETA (20:4 n-3)	29%	22%	0.6	.51	25%	26%	1.0	.94
EPA	21%	30%	1.7	.46	25%	26%	1.1	.93
DPA n-3	25%	26%	1.0	.99	21%	30%	1.7	.45
DHA	25%	26%	1.1	.91	21%	30%	1.7	.42
4-HDHA	8%	42%	8.0	.015	25%	26%	1.1	.91
10-HDHA	17%	33%	2.6	.17	22%	30%	1.6	.48
14-HDHA	17%	33%	2.8	.15	25%	25%	1.0	.98
17-HDHA	18%	36%	2.8	.15	18%	33%	2.3	.24
19,20-EpDPA	12%	39%	4.8	.041	17%	35%	2.6	.16
Other
Mead	21%	30%	1.7	.45	25%	26%	1.1	.87

^*Each compound was dichotomized according to median split at each timepoint. Odds ratios and p-values were from logistic regressions adjusted for age and parity.Due to the selection process for inclusion in this substudy, the overall risk of preterm birth is 25%.

^**9,10-EpOME & 9,10,13-TriHOME had >50% values below LOQ. Concentrations: fatty acids (ug/mL); oxylipins (ng/mL).