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. 2022 Jul 25;13(8):1302–1310. doi: 10.1021/acsmedchemlett.2c00215

Table 1. In Vitro Activity (MIC90 in μM) of 4a, 4b, 5a, and 5b and the Two Reference BTZs 1a and 1b against M. smegmatis mc2 155, M. aurum DSM 43999 and M. tuberculosis H37Rv.

  M. smegmatis mc2 155a M. aurum DSM 43999b M. tuberculosis H37Rvb
1a 6.25 25–12.5 >4.0
1b (BTZ043) 0.025 0.008 <0.06
4a 0.20 0.10 1.0
4b 0.32 0.25–0.13 0.5
5a >100 >100 >32
5b >100 >100 >32
a

7H9 medium supplemented with ADS.

b

7H9 medium supplemented with OADC.