Table 2.
Changes of DAO Levels and Cognitive Function During the 2-year Period
| Variable | DAO level, ng/mL | ADAS-cog | MMSE |
|---|---|---|---|
| Healthy elderly (n = 21) | |||
| Baseline | 50.6 (17.2) | 3.3 (1.7) | 29.0 (1.1) |
| 6 mo | 76.5 (35.5) | 2.9 (1.3) | 28.6 (1.5) |
| 12 mo | 94.2 (64.7) | 3.1 (1.9) | 28.2 (1.0) |
| 18 mo | 103.3 (56.3) | 2.9 (1.4) | 28.4 (1.2) |
| 24 mo | 93.2 (42.4) | 3.1 (1.5) | 28.2 (1.3) |
| P value of paired t test (baseline vs 24 mo) | <.001 | .596 | .029 |
| MCI patients (n = 51) | |||
| Baseline | 61.8 (35.9) | 9.5 (7.0) | 25.1 (3.8) |
| 6 mo | 78.1 (60.5) | 8.9 (5.9) | 25.4 (3.3) |
| 12 mo | 91.0 (39.9) | 9.5 (6.3) | 24.8 (3.9) |
| 18 mo | 95.3 (48.8) | 10.7 (8.2) | 24.1 (4.3) |
| 24 mo | 117.7 (57.9) | 11.5 (9.3) | 23.8 (4.2) |
| P value of paired t test (baseline vs 24 mo) | <.001 | .015 | .0004 |
Abbreviations: ADAS-cog, the Alzheimer’s Disease Assessment Scale-Cognitive Subscale; DAO, D-amino acid oxidase; MCI, mild cognitive impairment; MMSE, Mini Mental Status Examination.
The values in parentheses are SD values.