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. 2022 Apr 20;25(8):645–659. doi: 10.1093/ijnp/pyac026

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© The Author(s) 2022. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Cytokine and P2X7R levels in mouse plasma. (A,F) The levels of IL-1β and TNF-α did not significantly differ among the groups. (B,C,E) The plasma levels of IL-6, IL-10, and IL-17 were significantly increased in saline (SAL) + phencyclidine (PCP)-treated mice compared with SAL+SAL control mice. Risperidone (RIS) pretreatment (RIS+PCP) normalized the levels of all 3 of these cytokines. (D) The levels of IL-12 were significantly increased in the RIS+PCP group compared with the SAL+PCP and SAL+SAL groups. (G) The P2X7R concentrations did not significantly differ among the 4 groups. SAL+SAL: n=12; SAL+PCP: n=8; RIS+SAL: n=8; RIS+PCP: n=14. The data were analyzed by 2-way ANOVA followed by Tukey’s post hoc test. P values and statistical details are provided in supplementary Table 3. Abbreviations: ANOVA, analysis of variance; IL, interleukin; P2X7R, P2X7 receptor; TNF-α, tumour necrosis factor alpha.