Table 1.
Comparison of Patients Who Did and Did Not Receive Carbapenems as Antibiotic Prophylaxis
| Carbapenem Group (n = 27) | Non-Carbapenem Group (n = 78) | p | |
|---|---|---|---|
| Age (years) (media [±SD]) | 48.8±12.1 | 48.2±11.4 | 0.818 |
| Sex, male | 22 (81.5%) | 60 (76.9%) | 0.622 |
| BMI | 25.4±6.8 | 26.9±8.3 | 0.415 |
| Pre-LT ICU stay | 12 (44.4%) | 17 (21.8%) | 0.023 |
| Child–Pugh Score | 12.0±1.2 | 11.6±1.3 | 0.162 |
| MELD score (media [±SD]) | 35.2±3.9 | 33.4±3.5 | 0.030 |
| Underlying liver disease* | |||
| HBV | 21 (77.8%) | 59 (75.6%) | 0.822 |
| HCC | 0 (0%) | 1 (1.2%) | 1.000 |
| Alcohol | 5 (18.5%) | 5 (6.4%) | 0.120 |
| AIH | 0 (0%) | 6 (7.7%) | 0.335 |
| PBC | 0 (0%) | 3 (3.8%) | 0.567 |
| Others | 3 (11.1%) | 12 (15.4%) | 0.755 |
| Graft type | 0.382 | ||
| DBD | 9 (33.3%) | 15 (19.2%) | |
| DBCD | 5 (18.5%) | 12 (15.4%) | |
| DCD | 13 (48.1%) | 50 (64.1%) | |
| Living donor | 0 (0.0%) | 1 (1.3%) | |
| Cold ischemia time (min), media (±SD) | 547.5±137.7 | 523.4±164.4 | 0.528 |
| Warm ischemia time (min), media (±SD) | 9.0±11.0 | 10.4±9.2 | 0.545 |
| Intraoperative bleeding of ≥1500 mL | 15 (55.5%) | 27 (34.6%) | 0.056 |
| Vasopressor support within 24 h after LT | 8 (29.6%) | 3 (3.8%) | 0.001 |
| Intra-abdominal hemorrhage | 2 (7.4%) | 4 (5.1%) | 0.646 |
| Vascular complications | 0 (0%) | 4 (5.1%) | 0.570 |
| Biliary complications | 2 (7.4%) | 7 (9.0%) | 1.000 |
| Reoperation | 5 (18.5%) | 11 (14.1%) | 0.582 |
| Ventilation for >72 h | 15 (55.6%) | 14 (17.9%) | 0.000 |
| Renal replacement therapy for >3 days | 10 (37.0%) | 16 (20.5%) | 0.086 |
| Infection within 30 days after LT | 18 (66.7%) | 30 (38.5%) | 0.011 |
| CRO infection | 5 (18.5%) | 9 (11.5%) | 0.345 |
Note: *Some patients presented more than one cause of liver disease.
Abbreviations: AIH, autoimmune hepatitis; BMI, body mass index; CRO, carbapenem-resistant organism; DBD, donation after brain death; DBCD, donation after brain death followed by circulatory death; DCD, donation after circulatory death; ICU, intensive care unit; LT, liver transplantation; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; MELD, Model for End-Stage Liver Disease; PBC, primary biliary cirrhosis; SD, standard deviation.