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. 2022 Aug 16;18(8):e1010332. doi: 10.1371/journal.pgen.1010332

Fig 5. NKILA repress the metastasis of NPC by inhibiting the NF-kB pathway.

Fig 5

(A) NKILA expression in NPC cell lines determined by qRT-PCR assay (Mean ± SD, n = 3, ***, P < 0.001, **, P < 0.01versus NP69). (B) Representative images of migrated and invaded NPC cells with overexpressed or silenced NKILA in Boyden chamber assay (Mean ± SD, n = 3, ***, P < 0.001, versus control). (C) Representative images of the lung metastasis, metastatic nodes were indicated by Arrowheads. Left: Representative lungs, Right: Representative image (×200) of lung with metastasis by H&E staining. (D) 6 weeks after tail vein injection, number of metastases in lungs of each mice (mean±SD) were calculated. (E) The wet lung weight of the mice treated with the control vehicle was significantly higher, suggesting that mouse in control group had more or greater metastases, indicating that NKILA inhibited tumor metastasis.