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. 2022 Feb 7;33(6):607–629. doi: 10.1515/revneuro-2021-0133

Figure 4:

Figure 4:

Allostasis four-stage NFT model for neurophysiological regulation and adaptation.

(1) Brain as a regulator: A: Perceive (current internal and external state), B: Predict (output patterns, future internal & external state), and C: Regulate (determine an efficient trade-off or set-point). (2) Brain as an effector: Adapt (respond efficiently and flexibly to demands).