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. 2022 Apr 3;21(6):1020–1029. doi: 10.1158/1535-7163.MCT-21-0442

Figure 3.

Figure 3. Prediction of drug sensitivity using phosphoproteomic analysis. A, Classification of cell line–drug single-agent sensitivities into four quartiles, with Q1 = most sensitive and Q4 = least sensitive. B, Feature importance of phosphoproteins based on elastic net analysis shown. Features are described previously as significant if the weight is greater than + 0.1 or lesser than −0.1. C, Performance of predictions of sensitivity quartile based on phosphoproteomic changes using elastic net analysis. D, Performance of prediction of sensitivity quartile based on three clinically-relevant mutations (EGFR, PIK3CA, and KRAS) using elastic net analysis.

Prediction of drug sensitivity using phosphoproteomic analysis. A, Classification of cell line–drug single-agent sensitivities into four quartiles, with Q1 = most sensitive and Q4 = least sensitive. B, Feature importance of phosphoproteins based on elastic net analysis shown. Features are described previously as significant if the weight is greater than +0.1 or lesser than −0.1. C, Performance of predictions of sensitivity quartile based on phosphoproteomic changes using elastic net analysis. D, Performance of prediction of sensitivity quartile based on three clinically relevant mutations (EGFR, PIK3CA, and KRAS) using elastic net analysis.