Table 5.
Associations of circulating levels of free and total testosterone and SHBG (tertiles) with colon cancer in EPIC and NSHDS by tumor site.
| Tertile 1 | Tertile 2 | Tertile 3 | P trend | Continuousa | P heterogeneity | |
|---|---|---|---|---|---|---|
| Testosterone | 0.43 | |||||
| Proximal colon (n = 592) | ||||||
| n (case/control) | 118/99 | 86/105 | 92/92 | |||
| Multivariable-adjusted OR (95% CI)b | 1.00 | 0.67 (0.43–1.03) | 0.91 (0.57–1.46) | 0.69 | 0.81 (0.55–1.21) | |
| Distal colon (n = 748) | ||||||
| n (case/control) | 157/123 | 114/118 | 103/133 | |||
| Multivariable-adjusted OR (95% CI)b | 1.00 | 0.72 (0.48–1.09) | 0.62 (0.39–0.97) | 0.04 | 0.61 (0.41–0.91) | |
| Free testosterone | 0.72 | |||||
| Proximal colon (n = 592) | ||||||
| n (case/control) | 120/96 | 79/102 | 97/98 | |||
| Multivariable-adjusted OR (95% CI)b | 1.00 | 0.63 (0.41–0.96) | 0.84 (0.52–1.34) | 0.40 | 0.85 (0.50–1.43) | |
| Distal colon (n = 748) | ||||||
| n (case/control) | 135/126 | 111/120 | 128/128 | |||
| Multivariable-adjusted OR (95% CI)b | 1.00 | 0.86 (0.58–1.26) | 0.96 (0.63–1.46) | 0.87 | 0.89 (0.55–1.46) | |
| SHBG | 0.36 | |||||
| Proximal colon (n = 592) | ||||||
| n (case/control) | 114/94 | 94/103 | 88/99 | |||
| Multivariable-adjusted OR (95% CI)b | 1.00 | 0.79 (0.53–1.19) | 0.79 (0.49–1.27) | 0.30 | 0.89 (0.65–1.22) | |
| Multivariable-adjusted OR (95% CI)c | 1.00 | 0.79 (0.52–1.20) | 0.79 (0.43–1.43) | 0.52 | 1.02 (0.64–1.64) | |
| Distal colon (n = 748) | ||||||
| n (case/control) | 160/131 | 123/118 | 91/125 | |||
| Multivariable-adjusted OR (95% CI)b | 1.00 | 0.87 (0.59–1.28) | 0.67 (0.42–1.06) | 0.09 | 0.71 (0.52–0.96) | |
| Multivariable-adjusted OR (95% CI)c | 1.00 | 0.94 (0.63–1.40) | 0.78 (0.46–1.35) | 0.38 | 0.69 (0.44–1.07) |
aOR per 1-log2 unit increment.
bAdjusted for BMI (continuous), smoking status (current, former, never, unknown), physical activity (active, moderately active, moderately inactive, inactive), and alcohol consumption (zero, below median, above median).
cAdditionally adjusted for levels of estradiol and testosterone.