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. 2022 Aug 16;39(11):160. doi: 10.1007/s12032-022-01740-w

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Fig. 3 — Cladogram representing the evolutionary origin and expansion of the genetic toolkit for cell communication in animals (a). Bars represent the presence of the corresponding protein or protein family based on genome comparisons. The fate of these toolkits in cancer is also marked, if upregulated, downregulated, or dysregulated, and families that include genes involved in EMT/MET are indicated (b). Proto-oncogenes are marked in red; tumor suppressors are marked in green (Color figure online)