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. 2022 Aug 16;13:4822. doi: 10.1038/s41467-022-32401-1

Fig. 6. Irf8 is important for innate immunity to DNA virus in vivo.

Fig. 6

a Survival kinetics of WT (n = 11, female, 8 weeks old) and Irf8−/− mice (n = 8, female, 8 weeks old) after injection with HSV-1 (1 × 107 PFU per mouse). Data was analyzed by log-rank test. b Serum cytokine levels of WT and Irf8−/− mice (n = 6 per strain, female, 8 weeks old) injected intraperitoneally with HSV-1 (1 × 107 PFU per mouse) for 6 h. c qPCR analysis of Ifnb1 and Cxcl10 mRNA levels in lungs (left) and livers (right) of WT and Irf8−/− mice (n = 6 per strain, female, 8 weeks old) injected intraperitoneally with HSV-1 (1 × 107 PFU per mouse) for 24 h. d Plaque assays for viral titers in lungs and livers of WT and Irf8−/− mice (n = 4 per strain, female, 8 weeks old) injected intraperitoneally with HSV-1 (1 × 107 PFU per mouse) for 3 days. e, f qPCR analysis of Ifnb1 and Cxcl10 mRNA levels (e) and plaque assays for HSV-1 titers (f) in brains of WT and Irf8−/− mice (n = 4 per strain, female, 8 weeks old) injected intraperitoneally with HSV-1 (1 × 107 PFU per mouse) for 4 days. Data in bf are shown as mean ± SEM. Data were analyzed by unpaired two-tailed Student’s t-test. Source data are provided as a Source data file.