Table 1.
LDSC genetic correlation analyses between the various phenotypes, including internal controls and replication with PGC.
| Phenotype 1 (numbers of case;controls) | Phenotype 2 (numbers of case;controls) | rg | SE | P |
|---|---|---|---|---|
| iPSYCH ASD with a history of maternal pregnancy-related infections (623;21,429) | iPSYCH ASD with no history of maternal infections (6936;21,429) | 0.3811 | 0.1299 | 0.0033 |
| iPSYCH ASD with a history of maternal pregnancy-related infections (623;21,429) | PGC ASD phenotypea (replication) (5305;5305) | 0.3997 | 0.1552 | 0.0100 |
| iPSYCH ASD with no history of maternal infections (6936;21,429) | PGC ASD phenotype (replication) (5305;5305) | 0.6735 | 0.0944 | 9.71 × 10−13 |
| iPSYCH ASD irrespective of maternal infections (12,331;21,429) | PGC ASD phenotype (replication) (5305;5305) | 0.6344 | 0.0830 | 2.12 × 10−14 |
| iPSYCH ASD with maternal infections occurring only more than 2 months after childbirth (1861;21,429) | iPSYCH ASD with no history of maternal infections (6936;21,429) | 1.1199 | 0.2565 | 1.26 × 10−5 |
| iPSYCH ASD with maternal infections occurring only more than 2 months after childbirth (1861;21,429) | PGC ASD phenotype (replication) (5305;5305) | 0.6293 | 0.2134 | 0.0032 |
The p values are for tests for a difference from an rg of zero.
SE standard error; rg genetic correlation estimate; P p value.
aThe PGC study used cases and pseudocontrols.