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. 2022 Aug 16;12:13859. doi: 10.1038/s41598-022-18075-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Development of the flow upstream of the construct within CC1 and CC2, analyzed at three different horizontal sections. (a) Bottom part of CC1 with horizontal sections. (b) Bottom part of CC2 with horizontal sections. Contour plots of the velocity component along the longitudinal axis of the culture chamber with vectors of in-plane velocity components for the three horizontal sections of CC1 (c) and of CC2 (d).