Fig. 1.

A Apparent diffusion coefficient map image (3× zoom factor) in a 76-year-old man with a suspicious lesion in the peripheral zone indicated by the arrow (PI-RADS 4) that proved to be an ISUP grade 2 PCa (based on MRI-TRUS fusion). B 18-mm auto-fixed VOI placed around the voxel with the lowest ADC value; due to the location of the lesion, a large number of voxels outside the prostate are included (red outline). C Result of auto-fixed VOI combined with deep learning–based segmentation to remove unwanted voxels outside the prostate