Table 3.
Cardiac characteristics of patients with ATTRwt amyloidosis according to sex
| Overall (N = 1386) | Male (n = 1302) | Female (n = 84) | p value | |
|---|---|---|---|---|
| ATTR-CM (LV septum > 12 mm), n/N (%) | 949/1012 (94) | 898/956 (94) | 51/56 (91) | 0.387 |
| NYHA functional class, n/N (%) | 0.907 | |||
| I | 125/1183 (11) | 118/1110 (11) | 7/73 (10) | |
| II | 703/1183 (59) | 658/1110 (59) | 45/73 (62) | |
| III | 325/1183 (28) | 305/1110 (28) | 20/73 (27) | |
| IV | 30/1183 (3) | 29/1110 (3) | 1/73 (1) | |
| Pacemaker/ICD, n (%) | 198 (14) | 189 (15) | 9 (11) | 0.298 |
| NT-proBNP (pg/mL), n | 904 | 850 | 54 | |
| Mean (SD) | 4461 (7382) | 4378 (7249) | 5781 (9207) | 0.276 |
| Abnormal ECG, n/N (%) | 1116/1190 (94) | 1049/1116 (94) | 67/74 (91) | 0.216 |
| Complete AV block or pacemaker, n/N (%) | 441/1057 (42) | 420/993 (42) | 21/64 (33) | 0.136 |
| LAHB, n/N (%) | 166/723 (23) | 151/681 (22) | 15/42 (36) | 0.043 |
| LPHB, n/N (%) | 17/723 (2) | 17/681 (3) | 0/42 (0) | 0.616 |
| LBBB, n/N (%) | 105/724 (15) | 96/682 (14) | 9/42 (21) | 0.189 |
| RBBB, n/N (%) | 186/727 (26) | 174/685 (25) | 12/42 (29) | 0.648 |
| Diastolic interventricular septal wall thickness (mm), n | 1012 | 956 | 56 | |
| Mean (SD) | 17 (4) | 17 (4) | 17 (3) | 0.091 |
| Diastolic interventricular septal wall thickness (mm)/height (m), n | 996 | 940 | 56 | |
| Mean (SD) | 10 (2) | 10 (2) | 10 (2) | 0.456 |
| Diastolic posterior wall thickness (mm), n | 1018 | 961 | 57 | |
| Mean (SD) | 15 (3) | 16 (3) | 15 (3) | 0.076 |
| Diastolic posterior wall thickness (mm)/height (m), n | 1002 | 945 | 57 | |
| Mean (SD) | 9 (2) | 9 (2) | 9 (2) | 0.589 |
| LV mean wall thickness (mm), n | 1035 | 977 | 58 | |
| Mean (SD) | 16 (3) | 16 (3) | 16 (3) | 0.052 |
| LV mean wall thickness (mm)/height (m), n | 1019 | 961 | 58 | |
| Mean (SD) | 10 (2) | 10 (2) | 10 (2) | 0.460 |
| LV mass index (g/m2), n | 953 | 899 | 54 | |
| Mean (SD) | 166 (50) | 167 (49) | 159 (51) | 0.243 |
| LV diastolic diameter (mm), n | 1007 | 950 | 57 | |
| Mean (SD) | 45 (7) | 46 (7) | 42 (7) | < 0.001 |
| LV ejection fraction (%), n | 1030 | 974 | 56 | |
| Mean (SD) | 48 (12) | 48 (12) | 53 (13) | 0.001 |
| E wave deceleration time (ms), n | 502 | 477 | 25 | |
| Mean (SD) | 186 (56) | 186 (56) | 191 (58) | 0.656 |
| E wave/A wave ratio, n | 300 | 284 | 16 | |
| Median (Q1, Q3) | 2 (1, 3) | 2 (1, 3) | 2 (1, 2) | 0.334 |
ATTR-CM transthyretin amyloid cardiomyopathy; ATTRwt amyloidosis wild-type transthyretin amyloidosis; AV atrioventricular; ECG electrocardiogram; ICD implantable cardioverter defibrillator; LAHB left anterior hemiblock; LBBB left bundle branch block; LPHB left posterior hemiblock; LV left ventricular; NT-proBNP N-terminal pro-B-type natriuretic peptide; NYHA New York Heart Association; Q quartile; RBBB right bundle branch block; SD standard deviation