Why carry out this study?

Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) is a progressive, fatal disease that is primarily characterized by cardiomyopathy and is most often diagnosed in males

This analysis from the Transthyretin Amyloidosis Outcomes Survey (THAOS) examined sex differences in demographic and clinical characteristics of patients with ATTRwt amyloidosis

What was learned from the study?

Female patients with ATTRwt amyloidosis in THAOS tended to present at a later age and showed signs of less severe cardiac impairment and more severe neurologic impairment compared with male patients

These findings are suggestive of differences in the clinical presentation of ATTRwt amyloidosis between male and female patients