Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 16;13:4827. doi: 10.1038/s41467-022-32552-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Compared to the conventional gene set, the SenMayo list is significantly enriched during the aging process in murine brain microglia (p = 0.1565 vs. p = 0.0052; GSE145265), n = 4 (2 young, 2 aged, all ♂), b murine prefrontal cortex (p = 0.1169 vs. p = 0.0013; GSE128770), n = 48 (24 young, 24 aged, all ♂), and (c) murine dorsal hippocampus (p = 0.1916 vs. p < 0.001; GSE94832), n = 12 (6 young (3 ♀), 6 aged (2♀). Likewise, the murine bone marrow (d) within the tabula muris senis (GSE149590¹⁰²) has a higher enrichment of the SenMayo genes within the old cohort (p = 0.6043 vs. p = 0.0362), n = 11 (4 young (2 ♂, 2 ♀), 7 old (7 ♂, 0 ♀). Nominal p values were calculated as two-sided t-test, no adjustment since only one gene set was tested. Source data are provided as a Source Data file.