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Future outlook of in vitro H&N cancer patient-derived organoid (PDO) models. (A) Sourcing of H&N PDO models using the tumor biopsies of cancer patients and CRISPR DNA–modified healthy cells. (B) Fabrication of H&N PDO models using bioprinting. (C) H&N PDO model life span used as air–liquid interface in HTS for personalized medicine purposes. Figure created with BioRender.com.
