Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 16;12:13846. doi: 10.1038/s41598-022-18052-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Locations of missense variation that confer NADase LoF in the SARM1 TIR domain crystal structure. Ribbon diagram of the reported crystal structure of the human SARM1 TIR domain showing the locations of residues that are altered by the natural missense coding variants identified in this study to cause LoF. The structure presented is based on PDB ID:6O0R (bound to ribose) with the position of the predicted NAD substrate-binding pocket indicated by a star. Two views are shown differing by a rotation of 90° anti-clockwise along the vertical axis. The locations of residues that are altered to confer basic LoF are shown in dark blue and those that are altered to confer dominant LoF properties are shown in cyan. The catalytic E642 residue is labelled magenta. ChimeraX (http://www.rbvi.ucsf.edu/chimerax/) was used to generate the structures shown.