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. 2022 Aug 3;13:940645. doi: 10.3389/fimmu.2022.940645

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Copyright © 2022 Feng, Shan, Xia, Zheng, He, Wei, Song, Meng, Liu, Hao, Liang, Wang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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T cells of keloid and normal skin tissues were subdivided into different cell subsets. (A) Six different subsets of T cells are identified in keloid and normal tissues: CD4+ naïve T cells (CD4NaiveT), CD4+ effector memory T cells (CD4Tem), CD8+ effector T cells (CD8Teff), CD8+ mucosa-associated invariant T cells (CD8MAIT), CD4+ regulatory T cells (Treg), and proliferating T cells. (B) The ratio of six T-cell subsets in keloid and adjacent normal tissues is shown. (C) Heatmap illustrating representative differentially expressed genes among the six T-cell subsets. (D) Augur analysis indicates that proliferative T cells are the cell type with the greatest variation among subsets. (E) Enrichment analysis of differentially expressed genes in the six T-cell subpopulations.