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. 2022 Aug 3;13:940645. doi: 10.3389/fimmu.2022.940645

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Copyright © 2022 Feng, Shan, Xia, Zheng, He, Wei, Song, Meng, Liu, Hao, Liang, Wang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential ligand–receptor interactions analysis in fibroblast subpopulations. (A) Heatmap showing the numbers of interpopulation communications with each other in keloid and adjacent normal tissue. (B) The ligand–receptor pairs exhibit significant changes in specificity between any one of the populations and any one type of fibroblast in adjacent normal tissue versus keloid. (C) Putative and relative signaling or transcriptional factors (TFs) within fibroblasts and other cell populations’ keloid and adjacent normal tissue.