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. 2022 Aug 16;12:13908. doi: 10.1038/s41598-022-17730-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Patterns of EZH2 and BEND3 during peri-implantation development. (a, c) Upper panels show the Z-projection of a whole embryo at 2-, 4-, 8- and 16-cell (a) and at E3.5, E4.0 and E5.5 (c). Lower panels show a representative nucleus at each stage after staining with DAPI (green) and EZH2 (red). Arrows point to a chromocenter using to draw the intensity profile shown in (b) and (d). (e, g) Upper panels show the Z-projection of a whole embryo at 2-, 4-, 8- and 16-cell (e) and at E3.5, E4.0 and E5.5 (g). Lower panels show a representative nucleus at each stage after staining with DAPI (green) and BEND3 (red). Arrows point to a chromocenter using to draw the intensity profile shown in (f) and (h). Graphs were generated using ggplot2⁵⁶ (v3.3.5) in R and figures were arranged with FigureJ⁵⁵ in Fiji⁵⁴ (v1.53c).