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. 2022 May 26;127(4):747–756. doi: 10.1038/s41416-022-01821-7

Fig. 5. Mutational signature analyses in the WES cohort.

Fig. 5

a Trinucleotide motif frequency plot of the three de novo mutational profiles associated with SSN-LUADs. b Cosine similarity comparison between de novo mutational profiles and mutation patterns of 30 validated cancer signatures reported from the COSMIC database (green) and 53 carcinogen signatures reported from Kucab et al. (red). c Bar plots of de novo mutational signatures by individual tumours. d Distribution of de novo mutational signatures by radiological subtype. COSMIC catalogue of somatic mutations in cancer.