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. 2022 Aug 16;12:13886. doi: 10.1038/s41598-022-17727-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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P-value maps of associations of general cognitive ability (GCA) and change in cortical characteristics in the UKB, controlled for the effect of education and polygenic scores (PGSs) for education and GCA over time. The significant regions are shown for the interaction of GCA at baseline (with genetic ancestry factors regressed out) and time (interval from baseline scan), when age, sex, time, GCA, education, and the interactions of education by time, and PGSs by time, are controlled for (p < 0.01, corrected using a cluster-forming threshold of p < 0.01). Regions are shown, from left to right for each panel: right and left lateral view, right and left medial view. No significant regions were seen for cortical area.