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. 2022 Aug 16;13:4828. doi: 10.1038/s41467-022-32394-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Partial representation of MS2 network (cosine >0.7) for WT C. heterostrophus in ESI+, showing the cluster containing fumicicolin A (3) and the heterocicolins (10–13). Shown nodes are strongly upregulated in wildtype grown without copper (see Supplementary Fig. 4 for full network). b Relative abundance of fumicicolin A (3) in A. fumigatus, C. heterostrophus, and Penicillium spp., and its structural similarity with known d-mannitol derivatives, maculansin A (16) and brassicicolin A (17). c ESI + ion chromatograms of heterocicolins A (10), C (12), E (14), and F (15) in WT C. heterostrophus grown with (blue) or without copper (red) and ΔcrmA (green) grown without copper. Dashed arrows indicate fragmentation in MS2 spectra. In b, bars represent mean ± s.e.m. with six independent biological replicates for A. fumigatus and C. heterostrophus wildtype under copper-limited conditions and three for the other strains/conditions. Source data are provided as a Source Data file.