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. 2022 Aug 16;13:4812. doi: 10.1038/s41467-022-32437-3

Fig. 8. Basic residue distribution in the TMDs of ABCA1 and six established lipid flippases.

Fig. 8

The locations of tryptophan residues (space-filling magenta) are used to mark the membrane interfaces. In A, B, lysine residues and arginine residues are pale blue and dark blue, respectively. In C, intramembrane lysine residues and arginine residues are cyan. A ATP-free human ABCA1 (PDB entry 5XJY)13. B ATP-free S. Typhimurium MsbA (PDB entry 6BL6)62. C Six aligned structures of MsbA orthologs from three different bacterial species (PDB entries 2HYD, 3B5Z, 3B60, 5TTP, 5TV4, and 6BPP)6366.