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. 2022 Aug 3;12:933646. doi: 10.3389/fonc.2022.933646

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Copyright © 2022 Zhang, Tang, Guo, Wang, Zhou and Cai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentrations of (A) TNF-α, (B) IFN-γ, (C) IL-10, (D) IL-2, (E) PF, and (F) Gzms-B in the tumor microenvironment with the administration of nab-PTX and anti-PD-1 antibody (n = 3, biological duplicates). TNF-α, tumor necrosis factor α; IFN-γ, interferon-gamma; IL-10, interleukin 10; IL-2, interleukin 2; PF, perforin; Gzms-B, granzymes B. The data were from three independent biological replicates with one-way ANOVA followed by Tukey’s multiple comparisons. **p< 0.01, ***p< 0.001, ****p< 0.0001.