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. 2022 Aug 3;12:933646. doi: 10.3389/fonc.2022.933646

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Copyright © 2022 Zhang, Tang, Guo, Wang, Zhou and Cai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Serpinc1 gene overexpression on the expression of genes and proteins involved in cellular migration, invasion, cycle, and apoptosis. (A) N-cadherin, E-cadherin, p53, Survivin, CyclinD1, Bcl-2, and Bax mRNA in non-transfected blank, empty vector control, and Serpinc1 overexpressing cells (n = 3). (B) Expression levels of N-cadherin, E-cadherin, p53, Survivin, CyclinD1, Bcl-2, and Bax proteins were determined by Western blotting (n = 3). (C) The phosphorylation of Pi3K and AKT was determined by Western blot analysis (n = 3). p-values were analyzed by two-way ANOVA with Tukey’s multiple comparisons; comparison between the control vector and Serpinc1 overexpression. *p< 0.05, **p< 0.01, ***p< 0.001, ****p< 0.0001. Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X protein; AKT, protein kinase B; Pi3K, phosphatidylinositol 3-kinase.