Table 2B.
Univariate analyses and ANCOVA analyses.
| ANCOVA analyses | |||||
|---|---|---|---|---|---|
| Covariate | Group | Geometric mean | Lower confidence limit | Upper confidence limit | p-value |
| Birth weight (kg) | No LP | 1.93 | 1.46 | 2.55 | 0.0029 |
| LP | 1.06 | 0.81 | 1.40 | ||
| Duration of PN | No LP | 1.71 | 1.38 | 2.13 | 0.0283 |
| LP | 1.20 | 0.97 | 1.49 | ||
| DOL of onset of enteral feeding tolerance | No LP | 1.95 | 1.45 | 2.61 | 0.0060 |
| LP | 1.06 | 0.79 | 1.41 | ||
| DOL of reaching full enteral feeds | No LP | 1.55 | 1.25 | 1.90 | 0.0360 |
| LP | 1.12 | 0.91 | 1.38 | ||
| Presence of SBS | No LP | 2.80 | 2.02 | 3.88 | 0.0062 |
| LP | 1.66 | 1.14 | 2.42 | ||
| Presence of NEC | No LP | 2.13 | 1.66 | 2.74 | 0.0138 |
| LP | 1.35 | 1.02 | 1.79 | ||
| Lipid type (SMOFlipid® vs. Intralipid®) |
No LP | 2.50 | 1.72 | 3.61 | 0.0008 |
| LP | 1.25 | 0.89 | 1.76 | ||
| Phototherapy | No LP | 2.05 | 0.94 | 4.47 | 0.0025 |
| LP | 1.06 | 0.51 | 2.20 | ||
| Duration of phototherapy (days) |
No LP | 1.95 | 1.46 | 2.59 | 0.0062 |
| LP | 1.04 | 0.77 | 1.41 | ||
ANCOVA models were run separately for each covariant to determine if there was a difference between the groups regarding direct bilirubin level. Mean peak direct bilirubin levels remained significantly lower in the light-protection group compared to the no light-protection group even after individually adjusting for risk factors.
LP, light protection; PN, parenteral nutrition; DOL, day of Life; SBS, short bowel syndrome; NEC, necrotizing enterocolitis; SMOFlipid, soy-MCT-olive oil-fish oil lipids/lipid emulsion (fish oil and plant based); Intralipid, lipid emulsion (plant-based).