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. 2022 Aug 3;9:956538. doi: 10.3389/fcvm.2022.956538

Figure 5.

Figure 5

Electrophysiological measurements of isolated cardiomyocytes from the left and right ventricle of dogs in sinus rhythm (SR) and after 1 mg/kg omipalisib twice a day (Omi). (A) Representative peak tail current tracings at −50 mV (arrow). (B) Current density of total IK (left graph, n = 27, unpaired t-test, not significant) and relative current density of IKs and IKr to total IK (right graph, n = 27, repeated measures two-way ANOVA with Bonferroni's multiple comparisons test SR vs. Omi, bar refers to p < 0.05). IKs refers to the current blocked by 500 nM HMR 1556 and IKr refers to the current blocked by 1 μM dofetilide (Dof). (C) Representative action potential tracings. Membrane potential (Vm). (D) Action potential duration at 90% of repolarization (APD90) and (E) short term variability (STV) of repolarization at SR (n = 7) and Omi (n = 16). Unpaired t-test, bar refers to p < 0.05. Data are presented as mean ± SD.