Table 3.
Electrophysiological parameters of anesthetized dogs (n = 10) before treatment (control) and after 1 mg/kg omipalisib treatment twice a day.
| Parameter | Control | Omipalisib | ||
|---|---|---|---|---|
| Baseline | Dofetilide | Baseline | Dofetilide | |
| RR | 1,000 ± 0 | 1,000 ± 0 | 1,000 ± 0 | 1,000 ± 0 |
| PP | 471 ± 54 | 615 ± 60* | 506 ± 64 | 661 ± 118*# |
| QRS | 123 ± 7 | 125 ± 7 | 134 ± 9* | 134 ± 8*∧ |
| QT | 364 ± 17 | 490 ± 37* | 432 ± 36* | 607 ± 48*∧# |
| JT | 241 ± 15 | 365 ± 39* | 298 ± 29* | 473 ± 48*∧# |
| LV MAPD | 248 ± 21 | 352 ± 52* | 282 ± 18 | 459 ± 54*∧# |
| RV MAPD | 222 ± 25 | 274 ± 29* | 271 ± 13* | 408 ± 35*∧# |
| ΔMAPD | 25 ± 15 | 75 ± 49 | 17 ± 12 | 41 ± 25 |
| STV LV MAPD | 0.70 ± 0.42 | 1.83 ± 0.84 | 0.94 ± 0.84 | 3.54 ± 2.84* |
| STV RV MAPD | 0.62 ± 0.24 | 1.13 ± 0.64 | 0.83 ± 0.49 | 5.26 ± 4.42*∧# |
Parameters in ms. Data as mean ± SD. PP interval: n = 9. Monophasic action potential duration from the left ventricle (LV MAPD, n = 9) and right ventricle (RV MAPD, n = 8) at 80% of repolarization. ΔMAPD = LV MAPD – RV MAPD. STV = short term variability. Repeated measures two-way ANOVA with Tukey's multiple comparisons test, *p < 0.05 compared to control baseline, ∧p < 0.05 compared to control dofetilide, and #p < 0.05 compared to omipalisib baseline.